Protein Engineering Scientist

Job Juncture
June 11, 2021
South San Francisco, CA
Job Type


Start up biotech company in Bay Area is seeking a Protein Engineering Scientist to design and build high-content protein libraries using rational engineering methodologies.  This exciting new company is developing a proprietary technology platform to target various regenerative pathways critical for the establishment of complex diseases.

Requirements for the Protein Engineering Scientist:

  • PhD in molecular biology, genetics or related fields.  
  • 2+ years industry or post-doc experience\
  • A strong background in practical protein engineering, protein evolution, rational design methods, and an understanding of protein chemistry.
  • A solid understanding and experience in computational modeling of protein structure and domain analysis.
  • Prior experience setting up of high-throughput pipelines to functionally readout a large pool of protein variants, adoption of saturation mutagenesis strategy, or continuous directed evolution
  • A track record of accomplishment and publications in protein engineering
  • Creative mindset with a willingness to propose new approaches and ideas to improve the performance of specific proteins
  • Exceptional molecular biology skills (molecular cloning, DNA and RNA handling etc.
  • Background or knowledgable in DNA- and histone-binding proteins and their modifications preferred
  • CRISPR experience preferred

Responsibilities of the Protein Engineering Scientist:

  • Design and build high-content protein libraries using rational engineering methodologies

  • Use in vitro selection technologies to isolate proteins with desired properties

  • Optimize engineered proteins and antibodies through directed engineering efforts

  • Characterize engineered proteins in vivo biochemical assays

  • Develop screening assays (in vitro and in vivo) and selection methods for engineered protein variants

  • Document experiments and data

Occupational Category: 19-1029. Biological Scientists, All Other

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