Crispr Screening Scientist

September 2, 2021
South San Francisco, CA
Job Type


Yoh has an exciting opportunity for a CrispR Screening Scientist to support our Startup Biotechnology Client in San Francisco, CA. You would be working closely with scientists, research associates and other lab individuals. The successful candidate will perform CRISPR screening and have prior experience using gene editing, RNAi, CRISPRa/i, or CRISPR KO strategies. Please note this is an onsite, lab-based role.  This team functions as an in house CRO - you must be willing to do library screening; this is early stage work!

See below for complete job responsibilities and requirements. If after reviewing, you are interested in learning more about this, or other opportunities within the Biotech Industry, please apply with your updated resume ASAP. 

Title: CrispR Screening Scientist
Pay Rate: Competitive, depends on experience
Location: San Francisco, CA
Type: Full time regular hire

Checklist for successful candidates:

  • PhD in molecular biology, biotechnology, pharmaceutical, stem cell or related fields, with 2+ years of relevant research experience in industry or academia
  • Experience with high-throughput functional CRISPR screening; prior experience using gene editing, RNAi, CRISPRa/i, or CRISPR KO strategies
  • Working knowledge of NGS technologies and workflows
  • Ability to quickly learn new skills and knowledge on the job, demonstrate productivity, and deliver high-quality results

Exceptional candidates will also possess the following skills:

  • Experience in cellular reprogramming, adult stem cell such as HSCs, MSCs or SSCs culture
  • Familiarity with R or similar environments for pipelining of routine data analysis
  • Collaborative experience with computational biologists and/or software engineers to help develop and use novel tools for construct design, experimental planning and/or data analysis
  • Experience with multiplexing/barcoding approaches for scaling experimental throughput

What you will accomplish here:

  • Develop the high-throughput screening for a portfolio of cell therapy applications
  • Develop DNA constructs and CRISPR libraries
  • Develops, evaluates, optimizes and implements new technologies, laboratory protocols, and methodologies for biochemical and cell-based assays
  • Provide expert support for multiplexing and scaling biological readouts across our broader scientific team
  • Maintain familiarity with the relevant current literature and its application to multiplexing readouts and cell therapy
  • Coordinate tasks across multiple projects, demonstrating prioritization and planning
  • Interpret and effectively execute experiments in line with project timelines and goals


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