Principal Scientist, Biomarker Assay Development

July 29, 2022
South San Francisco, CA
Job Type


If you feel like youre part of something bigger, its because you are. At Amgen, our shared missionto serve patientsdrives all that we do. It is key to our becoming one of the worlds leading biotechnology companies. We are global collaborators who achieve togetherresearching, manufacturing, and delivering ever-better products that reach over 10 million patients worldwide. Its time for a career you can be proud of.

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What you will do

Lets do this. Lets change the world. In this vital role, you will be responsible for the development, validation and execution of clinical biomarker assays employing a variety of platforms to support our drug development efforts. The candidate will be an integral member of a dynamic group of scientists and platform experts.

The specific responsibilities include but are not limited to:

  • Collaborate with world-class scientists representing multiple therapeutic areas in the Clinical Biomarkers & Diagnostics organization and diverse groups of colleagues from other functional areas.

  • Employ a wide variety of platforms in our biomarker laboratory to develop and validate biomarker assays to support and advance various clinical programs.

  • Use cutting-edge tools and innovative approaches to generate, analyze, interpret and present data to the stakeholders.

  • Manage external partners to implement our biomarker strategies.


What we expect of you

We are all different, yet we all use our unique contributions to serve patients. The professional we seek is a highly motivated Scientist with these qualifications.

Basic Qualifications:

  • PhD degree with 3 years of scientific experience OR

  • Masters degree and 5 years of relevant experience OR

  • Bachelors degree and 7 years of proven experience

Preferred Qualifications:

  • Broad understanding of biomarker assay development and qualification process and guidelines

  • Basic understanding of disease biology and biomarker approaches in multiple therapeutic areas

  • Deep understanding of biomarker assay platforms particularly those that are used to assess soluble biomarkers such as ELISA Luminex, MSD, Simple-plex, Quanterix, O-Link and SomaLogic is required; knowledge of cell-based (including flow cytometry and immunohistochemistry) and genomics platforms is highly desirable

  • Experience working in a matrixed environment to execute biomarker assay development and validation employing innovative approaches to support clinical trials.

  • Experience mentoring and managing laboratory scientists.

  • Project management skills to meet critical timelines associated with various activities to support biomarker assessment of clinical samples.

  • Demonstrated track record of critical independent thinking, troubleshooting ability and innovative approaches to solve complex questions.

  • Ability to multi-task and handle multiple studies with creative and collaborative approach.

  • Must be able to work and coordinate with internal stakeholders as well as external partners such as CROs and vendors to support outsourced activities

  • Experience with complex data analysis and interpretation.


What you can expect of us

As we work to develop treatments that take care of others, we also work to care for our teammates professional and personal growth and well-being.

  • Vast opportunities to learn and move up and across our global organization

  • Diverse and inclusive community of belonging, where teammates are empowered to bring ideas to the table and act

  • Generous Total Rewards Plan comprising health, finance and wealth, work/life balance, and career benefits

Apply now

for a career that defies imagination

In our quest to serve patients above all else, Amgen is the first to imagine, and the last to doubt. Join us.

Amgen is an Equal Opportunity employer and will consider you without regard to your race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status.

We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation.

Amgen requires all staff in the United States and Puerto Rico to be vaccinated from COVID 19 as a condition of employment. In accordance with applicable law, Amgen will provide reasonable accommodations to staff members who qualify on the basis of a medical reason or a sincerely held religious belief, practice, or observance. Such accommodation may not pose an undue hardship to Amgen, its operations, or its staff.

Join Us

If you're seeking a career where you can truly make a difference in the lives of others, a career where you can work at the absolute forefront of biotechnology with the top minds in the field, you'll find it at Amgen.

Amgen, a biotechnology pioneer, discovers, develops and delivers innovative human therapeutics. Our medicines have helped millions of patients in the fight against cancer, kidney disease, rheumatoid arthritis and other serious illnesses.

As an organization dedicated to improving the quality of life for people around the world, Amgen fosters an inclusive environment of diverse, ethical, committed and highly accomplished people who respect each other but compete intensely to win. Together, we live the Amgen values as we continue advancing science to serve patients.

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