(Senior) Principal Scientist, Translational and Systems Pharmacology Modeling & Simulation

Published
May 5, 2022
Location
South San Francisco, CA
Category
Job Type

Description

(Senior) Principal Scientist, Modeling & Simulation, Translational & Systems Pharmacology, PKPD Group The Systems Pharmacology Group within the preclinical/translational PKPD Department at Genentech, Inc. is seeking a PKPD and Systems Modeling & Simulation Scientist who is driven to enhance drug development through quantitative modeling and simulation of PKPD and biological systems. The Translational and Systems Pharmacology Group at Genentech support projects in various stages of research and development and across a range of therapeutic areas and modalities. Our group is comprised of scientists with PhDs in computational disciplines with expertise in biology-based modeling and simulation, data-driven modeling, bioinformatics and systems biology, computational algorithm and tool development, and translating complex biology into quantitative models. We work closely with collaborators across all disciplines in therapeutic areas such as oncology and cancer immunotherapy, immune and inflammatory disorders, ocular disease, neurological disorders, and more. Efficient communication and collaboration with biological and clinical collaborators are critical skills. The group has a significant external presence, with a growing list of publications in highly regarded journals in the field, numerous oral presentations, academic seminars, and workshop leadership. Our members are leaders of various interest groups, conference programming committees, and working groups in the field of pharmaceutical modeling and simulation. In addition to our application of systems modeling approaches in support of drug development, we are also committed to the development of new technical approaches, algorithms, and tools to advance the field. Responsibilities Oversee, lead, and review efforts to develop and apply PKPD and QSP models in various therapeutic areas including immune & inflammatory disease, oncology, and other disease areas. The work can entail modeling of complex disease, cellular dynamics, intracellular signaling pathways, drug PK-PD relationships, and novel therapeutic approaches including new protein formats and delivery routes, cell therapy, and gene therapy. Strategize, plan, execute, and report QSP and PKPD modeling activities, and present work at cross-functional teams, department meetings, senior management review committees, regulatory interactions, and scientific conferences Depending on candidate qualifications, serve as dedicated personnel manager to scientists, interns, contractors within the group Work in close partnership with other scientists in Modeling and Simulation, Clinical Pharmacology, Clinical Science, Informatics, Biostatistics, Preclinical and Translational PK, DMPK, Safety Assessment, Biomarker, Diagnostics, Regulatory, and other functions. Explore, develop, and advance innovative methodologies and best practices in preclinical, translational and systems modeling including incorporation of novel data and analytics approaches such as machine learning, causal inference Adapt and thrive in an interactive, team-oriented culture. Qualifications Ph.D in: chemical, biomedical, or other relevant engineering fields, pharmaceutical sciences, applied mathematics, or related disciplines. Typical post-PhD experience requirements are: Principal Scientist, 7-12 years; Sr. Principal Scientist, 12 years. Proficiency with PKPD and systems modeling approaches such as differential equations, logic, stochastic, agent-based, and/or other advanced mechanistic modeling approaches is essential, as is experience with relevant software or programming languages (e.g., Simbiology, MATLAB, R, or C) Experience with other M&S and analytics approaches (e.g., statistics, statistical pharmacometrics, machine learning/artificial intelligence, systems biology/bioinformatics) is beneficial Excellent communication and interpersonal skills and the ability to work independently and effectively on cross-functional teams. Strong leadership skills and the ability to influence project team collaborators. Established leadership in the field including strong track record of scientific publications and presentations Personnel management experience preferred Job Level: Manager with direct reports This employer is a corporate member of myGwork - LGBTQ professionals, the business community for LGBTQ professionals, students, inclusive employers & anyone who believes in workplace equality.

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